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Estrogen receptors and biologic response in rat parathyroid tissue and C cells.

作者信息

Naveh-Many T, Almogi G, Livni N, Silver J

机构信息

Minerva Center in Calcium and Bone Metabolism, Nephrology Service, Jerusalem, Israel.

出版信息

J Clin Invest. 1992 Dec;90(6):2434-8. doi: 10.1172/JCI116134.

DOI:10.1172/JCI116134
PMID:1469095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC443399/
Abstract

The expression of the PTH and calcitonin genes is dramatically decreased by 1,25(OH)2D3 in vivo, and the PTH gene expression is increased by hypocalcemia. We have now studied the effect of estrogens on the expression of these genes in vivo. 17 beta-Estradiol, given to ovariectomized rats, led to a fourfold increase in PTH mRNA and calcitonin mRNA levels. These effects occurred 24 h after single injections of 37-145 nmol estradiol, or after constant infusions of 12 pmol/d for 1 or 2 wk, where there was no effect on serum calcium levels. The estrogen receptor mRNA was demonstrated in the thyroparathyroid tissue by polymerase chain reaction. The estrogen binding was localized to the parathyroid and C cells by immunohistochemistry. Uterus weight was increased by repeated larger doses (73 nmol/d x 7) of estradiol, but not by the small doses (12 pmol/d for 1 or 2 wk) which were effective on the PTH and calcitonin genes, suggesting a sensitive endocrine effect. These results confirm that the parathyroid and C cells are target organs for estrogen, leading to an increased expression of PTH and calcitonin, which by their combined anabolic effect on bone would help prevent osteoporosis.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/508dd3cf129e/jcinvest00054-0298-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/a900d830c222/jcinvest00054-0297-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/1a707476d0d1/jcinvest00054-0297-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/d255b4b7a034/jcinvest00054-0297-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/fc975892c857/jcinvest00054-0297-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/43fd46ca8230/jcinvest00054-0297-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/7bb03756bb5f/jcinvest00054-0298-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/508dd3cf129e/jcinvest00054-0298-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/a900d830c222/jcinvest00054-0297-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/1a707476d0d1/jcinvest00054-0297-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/d255b4b7a034/jcinvest00054-0297-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/fc975892c857/jcinvest00054-0297-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/43fd46ca8230/jcinvest00054-0297-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/7bb03756bb5f/jcinvest00054-0298-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3dc/443399/508dd3cf129e/jcinvest00054-0298-c.jpg

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本文引用的文献

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Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial.人甲状旁腺激素片段对绝经后骨质疏松症小梁骨的合成代谢作用：一项多中心试验。
Br Med J. 1980 Jun 7;280(6228):1340-4. doi: 10.1136/bmj.280.6228.1340.
2
Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis.雌激素对绝经后骨质疏松症患者钙吸收及血清维生素D代谢产物的影响
J Clin Endocrinol Metab. 1980 Dec;51(6):1359-64. doi: 10.1210/jcem-51-6-1359.
3
Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells.
甲状腺癌患者行甲状腺全切除术联合术中甲状旁腺自体移植后甲状旁腺功能减退症发生与恢复的相关因素。
Front Endocrinol (Lausanne). 2022 Jul 22;13:963070. doi: 10.3389/fendo.2022.963070. eCollection 2022.
4
Is There a Gender Difference in Clinical Presentation of Renal Hyperparathyroidism and Outcome after Parathyroidectomy?肾性甲状旁腺功能亢进的临床表现及甲状旁腺切除术后的结果存在性别差异吗？
Visc Med. 2020 Feb;36(1):34-40. doi: 10.1159/000505501. Epub 2020 Jan 20.
5
and Regulate Parathyroid Hormone Levels in Secondary Hyperparathyroidism.并调节继发性甲状旁腺功能亢进症中的甲状旁腺激素水平。
J Am Soc Nephrol. 2017 Aug;28(8):2353-2363. doi: 10.1681/ASN.2016050585. Epub 2017 Mar 15.
6
Parathyroid hormone and its receptor gene polymorphisms: implications in osteoporosis and in fracture healing.甲状旁腺激素及其受体基因多态性：对骨质疏松症和骨折愈合的影响
Rheumatol Int. 2016 Jan;36(1):1-6. doi: 10.1007/s00296-015-3319-9. Epub 2015 Jul 21.
7
Tamoxifen stimulates calcitonin-producing thyroid C-cells and prevents trabecular bone loss in a rat model of androgen deficiency.他莫昔芬可刺激产生降钙素的甲状腺C细胞，并在雄激素缺乏的大鼠模型中预防小梁骨丢失。
J Anat. 2015 May;226(5):489-96. doi: 10.1111/joa.12298. Epub 2015 Apr 7.
8
The effects of sex steroids on thyroid C cells and trabecular bone structure in the rat model of male osteoporosis.雄性骨质疏松大鼠模型中性类固醇激素对甲状腺 C 细胞和小梁骨结构的影响。
J Anat. 2013 Mar;222(3):313-20. doi: 10.1111/joa.12013. Epub 2012 Nov 21.
9
Regulation and function of the FGF23/klotho endocrine pathways.成纤维细胞生长因子 23（FGF23）/klotho 内分泌途径的调节和功能。
Physiol Rev. 2012 Jan;92(1):131-55. doi: 10.1152/physrev.00002.2011.
10
Demographic, dietary, and serum factors and parathyroid hormone in the National Health and Nutrition Examination Survey.国家健康与营养调查中的人口统计学、饮食和血清因素与甲状旁腺激素。
Osteoporos Int. 2012 Jun;23(6):1727-36. doi: 10.1007/s00198-011-1776-x. Epub 2011 Sep 20.
维生素D代谢产物对离体牛甲状旁腺细胞中甲状旁腺激素原信使核糖核酸的调节作用。
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4
Parathyroid hormone secretion: effect of estradiol and progesterone.
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Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat.维生素D代谢产物对大鼠体内甲状旁腺激素基因转录的调控
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Hip fracture and the use of estrogens in postmenopausal women. The Framingham Study.髋部骨折与绝经后女性雌激素的使用。弗明汉姆研究。
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10
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