Marković-Glamocak Mirjana, Sucić Mirna, Krizanac Simun, Ries Suncica, Gjadrov-Kuvezdić Koraljka, Boban Dubravka
Klinićki zavod za laboratorijsku dijagnostiku Medicinskog fakulteta Sveucilista u Zagrebu, Zavod za citologiju, Kispatićeva 12, 10 000 Zagreb.
Lijec Vjesn. 2003 Jul-Aug;125(7-8):180-3.
Morphologic changes in glandular epithelium of the breast after quadrantectomy of the breast carcinoma and radiotherapy are described. The aim of the study was to establish the possibilities of cytologic assessment of morphological changes in palpable lesions in the residual breast tissue. Fine needle aspirates of 50 patients after surgery and radiotherapy of the breast carcinoma were analyzed. Biopsy and pathohistologic verification were performed in 12 patients. Carcinoma was cytologically found and confirmed pathohistologically in two cases. Recurrence was pathohistologically confirmed in 3/10 (33.3%) cytologically suspect aspirates, while in the remaining 7/10 (66.7%) suspect findings benign changes were established (2 mild ductal proliferations, 2 florid ductal proliferations, 3 cases of adenosis). The patients were followed-up clinically and cytomorphologically. No relapse was noted in the follow up period. Although its role is limited, fine needle aspiration cytology is useful in the assessment and follow-up of palpable changes after irradiation. A cytologist should be informed on whether and when a patient underwent irradiation. The finding of the changed cell after the period without changes points to the relapse of the disease.
描述了乳腺癌象限切除术后及放疗后乳腺腺上皮的形态学变化。本研究的目的是确定对残留乳腺组织中可触及病变的形态学变化进行细胞学评估的可能性。分析了50例乳腺癌手术及放疗后患者的细针穿刺抽吸物。对12例患者进行了活检及病理组织学验证。在2例病例中细胞学发现了癌并经病理组织学证实。在10例细胞学可疑的抽吸物中，3/10（33.3%）经病理组织学证实为复发，而在其余7/10（66.7%）可疑结果中确定为良性改变（2例轻度导管增生、2例旺炽性导管增生、3例腺病）。对患者进行了临床及细胞形态学随访。随访期间未发现复发。尽管细针穿刺细胞学的作用有限，但它在评估放疗后可触及变化及随访方面是有用的。应告知细胞学家患者是否以及何时接受过放疗。在一段无变化时期后出现细胞改变提示疾病复发。
