Robertson Daniela, Hellweg Thomas, Tiersch Brigitte, Koetz Joachim
Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Str. 24/25, Haus 25, 14476 Golm, Germany.
J Colloid Interface Sci. 2004 Feb 1;270(1):187-94. doi: 10.1016/j.jcis.2003.09.013.
Aqueous concentrated lecithin mixtures (asolectin from soybean) show typical lamellar liquid crystalline behavior and the individual lamellae tend to form spherical supramolecular structures, i.e., multilamellar vesicles. When part of the lecithin is replaced by the anionic surfactant sodium dodecyl sulfate (SDS), the compact multilamellar vesicles disappear and the viscosity decreases. By adding poly(diallyldimethylammonium chloride) (PDADMAC) to the lecithin/SDS system, the formation of multilamellar vesicles can be induced again and the viscosity increases. However, one characteristic feature of these polymer-modified systems is a temperature-dependent phase transition from a compact multilamellar vesicle phase to a more swollen liquid crystalline phase. The polymer-modified multilamellar compact vesicles are of interest for utilization as new thermosensitive drug delivery systems.
水性浓缩卵磷脂混合物（大豆中的大豆卵磷脂）表现出典型的层状液晶行为，且单个片层倾向于形成球形超分子结构，即多层囊泡。当部分卵磷脂被阴离子表面活性剂十二烷基硫酸钠（SDS）取代时，紧密的多层囊泡消失且粘度降低。通过向卵磷脂/SDS体系中添加聚二烯丙基二甲基氯化铵（PDADMAC），可以再次诱导多层囊泡的形成且粘度增加。然而，这些聚合物改性体系的一个特征是从紧密的多层囊泡相到更膨胀的液晶相的温度依赖性相变。聚合物改性的多层紧密囊泡作为新型热敏药物递送系统具有应用价值。
