Rödström Per-Olof, Jontell Mats, Mattsson Ulf, Holmberg Erik
Clinic of Oral Medicine, Department of Endodontology & Oral Diagnosis, Faculty of Odontology, Göteborg University, Medicinaregatan 12, Box 450, SE 405 30 Göteborg, Sweden.
Oral Oncol. 2004 Feb;40(2):131-8. doi: 10.1016/s1368-8375(03)00134-9.
Oral lichen planus (OLP) is generally regarded as a premalignant condition. The objective of the present study was to assess the number of oral malignant tumours in a retrospective analysis of 1028 patients (mean age=55 years; range=18-86; female, n=667; men, n=351) who between 1978 to end of 1993 were diagnosed with OLP at the Faculty of Odontology, Göteborg University, Sweden. Patients with malignant tumours were identified through the Swedish Cancer Registry at the National Board of Health and Welfare, which annually reports the incidence of malignant neoplasms in the Swedish population. The incidence of oral squamous cancer (OSCC), other malignant tumours and survival in the study group was compared to the Swedish population. The total time with OLP in the study group amounted to 7009 person years, with a mean follow up of 6.8 years (SD=4.9). The observed incidence of OSCC was higher than the expected incidence in the study group. The difference was statistically significant (P<0.001). No statistically significant difference was found for any other malignant tumours than OSCC. Also, no statistically significant difference could be identified in survival between study group and the population. The results from the present study gives further support to the concept of a small but increased risk for development of squamous cell carcinoma in patients with OLP.
口腔扁平苔藓（OLP）通常被视为一种癌前病变。本研究的目的是对1978年至1993年底在瑞典哥德堡大学牙科学院被诊断为OLP的1028例患者（平均年龄55岁；范围18 - 86岁；女性667例，男性351例）进行回顾性分析，以评估口腔恶性肿瘤的数量。通过瑞典国家卫生与福利委员会的瑞典癌症登记处确定患有恶性肿瘤的患者，该登记处每年报告瑞典人群中恶性肿瘤的发病率。将研究组中口腔鳞状细胞癌（OSCC）、其他恶性肿瘤的发病率及生存率与瑞典人群进行比较。研究组中OLP的总人年数为7009人年，平均随访6.8年（标准差 = 4.9）。研究组中观察到的OSCC发病率高于预期发病率。差异具有统计学意义（P < 0.001）。除OSCC外，未发现其他任何恶性肿瘤有统计学意义的差异。此外，研究组与总体人群在生存率方面也未发现统计学意义的差异。本研究结果进一步支持了OLP患者发生鳞状细胞癌的风险虽小但有所增加这一概念。
