Bakker M K, Cornel M C, de Walle H E
Rijksuniversiteit Groningen, disciplinegroep Medische Genetica, EUROCAT Noord Nederland, Triadegebouw KZ00.10, Postbus 30.001, 9700 RB Groningen.
Ned Tijdschr Geneeskd. 2003 Dec 6;147(49):2426-30.
To investigate the influence of ethnicity on the awareness and use of folic acid by pregnant women.
Secondary data analysis.
Using the data on 1555 women, collected during a cross-sectional study conducted among pregnant women with good knowledge of the Dutch language in 1996, the authors determined what was known about the recommendation to use folic acid around the time of conception and what the actual use was. Women were defined as either 'western' or 'non-western' on the basis of the place of birth of the woman and her parents.
Of the 1555 pregnant women, 74 (5%) were non-western or of non-western descent. Non-western women more often had a lower educational level than western women (51% versus 34%; p = 0.002) and more often had an unintended pregnancy (24% versus 8%; p < 0.0001). 41% of the non-western women had heard of the recommendation to use folic acid before pregnancy, compared to 79% of the western women (p < 0.0001). However, the use of folic acid was not significantly different between non-western and western women (56% versus 69%) if they had been aware of the recommendation to use folic acid before pregnancy. Awareness of the recommendation to use folic acid was higher in older women (OR: 1.46; 95% CI: 1.13-1.89), women of western descent (0.27; 0.16-0.47), women with a higher level of education (0.35; 0.27-0.45) and in case of planned pregnancy (0.45; 0.31-0.67). The use of folic acid, restricted to women who were aware of the recommendation to use folic acid before their pregnancy, was higher in older women (1.37; 1.05-1.80) and lower in those with more previous pregnancies (0.57; 0.43-0.75) and in case of an unplanned pregnancy (0.55; 0.34-0.88).
Although non-western women had less knowledge of the recommendation to use folic acid than western women, the use of folic acid was not significantly different from that by western women if they had been aware of the recommendation to use folic acid before pregnancy. Continued education on folic acid targeting non-western and western women is important.
探讨种族对孕妇叶酸知晓率及叶酸使用情况的影响。
二次数据分析。
作者利用1996年在荷兰语良好的孕妇中进行的一项横断面研究收集的1555名女性的数据，确定她们在受孕前后对使用叶酸建议的了解情况以及实际使用情况。根据女性及其父母的出生地，将女性定义为“西方”或“非西方”。
在1555名孕妇中，74名（5%）为非西方或非西方血统。非西方女性的教育水平低于西方女性的情况更为常见（分别为51%和34%；p = 0.002），意外怀孕的情况也更为常见（分别为24%和8%；p < 0.0001）。41%的非西方女性在怀孕前听说过使用叶酸的建议，而西方女性这一比例为79%（p < 0.0001）。然而，如果非西方和西方女性在怀孕前知晓使用叶酸的建议，她们之间叶酸的使用情况并无显著差异（分别为56%和69%）。年龄较大的女性（比值比：1.46；95%置信区间：1.13 - 1.89）、西方血统的女性（0.27；0.16 - 0.47）、教育水平较高的女性（0.35；0.27 - 0.45）以及计划怀孕的女性（0.45；0.31 - 0.67）对使用叶酸建议的知晓率更高。仅针对怀孕前知晓使用叶酸建议的女性而言，年龄较大的女性叶酸使用率更高（1.37；1.05 - 1.80），而既往怀孕次数较多的女性（0.57；0.43 - 0.75）以及意外怀孕的女性（0.55；0.34 - 0.88）叶酸使用率较低。
尽管非西方女性对使用叶酸建议的知晓程度低于西方女性，但如果她们在怀孕前知晓该建议，其叶酸使用情况与西方女性并无显著差异。针对非西方和西方女性持续开展叶酸教育很重要。
