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Alcohol and inhibitory receptors: unexpected specificity from a nonspecific drug.

作者信息

Harris R A, Mihic S J

机构信息

Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, Institutes for Neuroscience and Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA.

出版信息

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):2-3. doi: 10.1073/pnas.0307281101. Epub 2003 Dec 26.

DOI:10.1073/pnas.0307281101
PMID:14695895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC314125/
Abstract
摘要

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本文引用的文献

1
Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans.乙醇在已知会影响人类的低浓度下会增强α4β3δ和α6β3δγ-氨基丁酸A型受体。
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15218-23. doi: 10.1073/pnas.2435171100. Epub 2003 Nov 18.
2
Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.受激素调节的α(4)β(2)δ GABA(A)受体是酒精作用的靶点。
Nat Neurosci. 2002 Aug;5(8):721-2. doi: 10.1038/nn888.
3
Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice.作为乙醇作用靶点的钾通道：对G蛋白偶联内向整流钾通道2（GIRK2）基因敲除突变小鼠的研究
J Pharmacol Exp Ther. 2001 Aug;298(2):521-30.
4
Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.醇类和麻醉剂在配体门控离子通道上的特异性结合位点。
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9305-10. doi: 10.1073/pnas.160128797.
5
Acute effects of ethanol on GABAA and glycine receptor function.乙醇对γ-氨基丁酸A受体和甘氨酸受体功能的急性影响。
Neurochem Int. 1999 Aug;35(2):115-23. doi: 10.1016/s0197-0186(99)00053-4.
6
Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes.亚基突变影响乙醇对非洲爪蟾卵母细胞中表达的GABA(A)受体的作用。
Br J Pharmacol. 1999 May;127(2):377-82. doi: 10.1038/sj.bjp.0702563.
7
Ethanol tolerance and withdrawal responses in GABA(A) receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and strain 129/SvJ mice.GABA(A)受体α6亚基无效等位基因小鼠以及近交系C57BL/6J和129/SvJ品系小鼠的乙醇耐受性和戒断反应
Alcohol Clin Exp Res. 1998 Feb;22(1):259-65.
8
Modulation of recombination human gamma-aminobutyric acidA receptors by isoflurane: influence of the delta subunit.异氟烷对重组人γ-氨基丁酸A受体的调节作用：δ亚基的影响
Anesthesiology. 1998 Jan;88(1):206-17. doi: 10.1097/00000542-199801000-00029.
9
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.酒精和挥发性麻醉剂对GABA(A)和甘氨酸受体的作用位点。
Nature. 1997 Sep 25;389(6649):385-9. doi: 10.1038/38738.
10
Anesthetic potencies of n-alkanols: results of additivity and solubility studies suggest a mechanism of action similar to that for conventional inhaled anesthetics.正链烷醇的麻醉效能：加和性与溶解性研究结果提示其作用机制与传统吸入麻醉药相似。
Anesth Analg. 1997 May;84(5):1042-8. doi: 10.1097/00000539-199705000-00017.