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Lineage specific differentiation of mouse ES cells: formation and differentiation of early primitive ectoderm-like (EPL) cells.

作者信息

Rathjen Joy, Rathjen Peter D

机构信息

Department of Molecular Biosciences, ARC Special Research Centre for the Molecular Genetics of Development, Adelaide University, Molecular Life Sciences/335, Adelaide, 5005, Australia.

出版信息

Methods Enzymol. 2003;365:3-25. doi: 10.1016/s0076-6879(03)65001-9.

DOI:10.1016/s0076-6879(03)65001-9
PMID:14696334
Abstract
摘要

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Lineage specific differentiation of mouse ES cells: formation and differentiation of early primitive ectoderm-like (EPL) cells.小鼠胚胎干细胞的谱系特异性分化：早期原始外胚层样（EPL）细胞的形成与分化。
Methods Enzymol. 2003;365:3-25. doi: 10.1016/s0076-6879(03)65001-9.
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Manipulation of cell:cell contacts and mesoderm suppressing activity direct lineage choice from pluripotent primitive ectoderm-like cells in culture.细胞与细胞接触的操控以及中胚层抑制活性可直接引导培养的多能原始外胚层样细胞的谱系选择。
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Pluripotency: capacity for in vitro differentiation of undifferentiated embryonic stem cells.多能性：未分化胚胎干细胞的体外分化能力。
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Formation of a primitive ectoderm like cell population, EPL cells, from ES cells in response to biologically derived factors.在生物衍生因子的作用下，胚胎干细胞形成原始外胚层样细胞群体，即EPL细胞。
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Spontaneous differentiation of mouse embryonic stem cells in vitro: characterization by global gene expression profiles.小鼠胚胎干细胞在体外的自发分化：通过全基因组表达谱进行表征
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Lineage specific differentiation of pluripotent cells in vitro: a role for extraembryonic cell types.多能干细胞在体外的谱系特异性分化：胚外细胞类型的作用。
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Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development.原始外胚层形成过程中的瞬时多能细胞群体：体内和体外多能细胞发育的相关性
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In vitro differentiation of mouse ES cells: bone and cartilage.小鼠胚胎干细胞的体外分化：骨骼与软骨
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Overexpression of Nodal promotes differentiation of mouse embryonic stem cells into mesoderm and endoderm at the expense of neuroectoderm formation.Nodal的过表达会促进小鼠胚胎干细胞分化为中胚层和内胚层，同时以牺牲神经外胚层的形成为代价。
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