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Anomalous phosphorylated neurofilament aggregations in central and peripheral axons of hens treated with tri-ortho-cresyl phosphate (TOCP).

作者信息

Jensen K F, Lapadula D M, Anderson J K, Haykal-Coates N, Abou-Donia M B

机构信息

Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27709.

出版信息

J Neurosci Res. 1992 Nov;33(3):455-60. doi: 10.1002/jnr.490330311.

DOI:10.1002/jnr.490330311
PMID:1469747
Abstract

Previous biochemical studies demonstrated a dramatic increase in phosphorylation of cytoskeletal proteins that occurs early in organophosphorus ester-induced delayed neurotoxicity (OPIDN). In this report we present immunohistochemical evidence that there is anomalous aggregation of phosphorylated neurofilaments within central and peripheral axons following organophosphate exposure. The morphology, location, and time of appearance of these aggregations are consistent with the hypothesis that the aberrant phosphorylation of cytoskeletal elements is an antecedent to the focal axonal swelling and degeneration characteristic of OPIDN.

摘要

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2
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