在一名多发性骨髓瘤治疗后继发性骨髓增生异常综合征患者中，运用反向染色体描绘技术对psu dic(6;5)(p21.3;q13)进行特征分析。
Characterization of psu dic(6;5)(p21.3;q13) with reverse chromosome painting in a patient with secondary myelodysplastic syndrome following treatment for multiple myeloma.
作者信息
Lee-Jones Lisa, Ramsahoye Bernard, Booth Margaret, Thompson Peter, Whittaker Jack, Hoy Terry
机构信息
Tumour Molecular Genetics Group, Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK.
出版信息
Cancer Genet Cytogenet. 2004 Jan 1;148(1):49-54. doi: 10.1016/s0165-4608(03)00218-8.
We report a case of a psu dic(6;5)(p21.3;q13) in a patient with secondary myelodysplastic syndrome (sMDS) following treatment for multiple myeloma. The abnormal chromosome was isolated by flow karyotyping and initially identified by reverse chromosome painting. The findings were then confirmed by forward painting. The value of flow karyotyping as a diagnostic technique in hematologic malignancies is discussed.
我们报告了一例在接受多发性骨髓瘤治疗后发生继发性骨髓增生异常综合征（sMDS）的患者，其存在假双着丝粒染色体dic(6;5)(p21.3;q13)。通过流式核型分析分离出异常染色体，并最初通过反向染色体涂染进行鉴定。随后通过正向涂染对结果进行了确认。本文讨论了流式核型分析作为血液系统恶性肿瘤诊断技术的价值。
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