治疗相关的骨髓增生异常综合征。一名多发性骨髓瘤患者体内两个细胞遗传学不相关的异常克隆。
Therapy-related myelodysplastic syndrome. Two cytogenetically unrelated abnormal clones in a patient with multiple myeloma.
作者信息
Abeliovich D, Yehuda O, Ben-Neriah S, Matzner Y
机构信息
Department of Human Genetics, Mount Scopus, Hadassah University Hospital, Jerusalem, Israel.
出版信息
Cancer Genet Cytogenet. 1993 Oct 15;70(2):117-9. doi: 10.1016/0165-4608(93)90179-p.
A multiple myeloma patient presented for cytogenetic analysis at diagnosis of secondary MDS, which followed cytotoxic treatment including melphalan. Two abnormal unrelated clones were detected, one of them had 5q-, 7q- with clonal evolution of an additional aberration, t(12;13); in the second clone there was a translocation between the two homologues of chromosome 1 as the only aberration. We suggest that the clone with 5q- and 7q- represented the secondary MDS cells, whereas the abnormal clone with t(1;1) represented the plasmablasts of the multiple myeloma.
一名多发性骨髓瘤患者在诊断为继发性骨髓增生异常综合征时接受了细胞遗传学分析，该患者此前接受了包括美法仑在内的细胞毒性治疗。检测到两个异常的不相关克隆，其中一个有5号染色体长臂缺失（5q-）、7号染色体长臂缺失（7q-），并伴有额外异常t(12;13)的克隆进化；在第二个克隆中，1号染色体的两个同源染色体之间发生了易位，这是唯一的异常。我们认为，具有5q-和7q-的克隆代表继发性骨髓增生异常综合征细胞，而具有t(1;1)的异常克隆代表多发性骨髓瘤的浆母细胞。
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