Pietrangeli P, Mondovì B
Department of Biochemical Sciences A Rossi Fanelli and CNR Centre of Molecular Biology, La Sapienza University of Rome, Ple Aldo Moro 5, 00185 Rome, Italy.
Neurotoxicology. 2004 Jan;25(1-2):317-24. doi: 10.1016/S0161-813X(03)00109-8.
The physiological function in living organisms of amine oxidases, is not completely established but is certainly related to the biogenic amines metabolism and therefore involved in essential processes such as the cell growth and differentiation. A correlation between degree of tumor malignancy and level of AO activity has been reported. The catalytic products of oxidative deamination of amines (hydrogen peroxide and aminoaldehyde) exert a cytotoxic effect and are considered cell growth inhibitors. The biogenic amines in same way could be considered in the cells as both poisons and protectors. A balance of oxidant and antioxidant enzymes appears to be very important in carcinogenesis and cell growth regulation.
胺氧化酶在生物体内的生理功能尚未完全明确，但肯定与生物胺代谢相关，因此参与细胞生长和分化等重要过程。有报道称肿瘤恶性程度与胺氧化酶活性水平之间存在关联。胺氧化脱氨的催化产物（过氧化氢和氨基醛）具有细胞毒性作用，被认为是细胞生长抑制剂。同样，生物胺在细胞内既可以被视为毒物，也可以被视为保护剂。氧化酶和抗氧化酶之间的平衡在致癌作用和细胞生长调节中似乎非常重要。
