Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors.
作者信息
Nakamura Toshio, Kakinuma Hiroyuki, Umemiya Hiroki, Amada Hideaki, Miyata Noriyuki, Taniguchi Kazuo, Bando Kagumi, Sato Masakazu
机构信息
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd, 1-403 330-8530, Yoshino-cho, Ohmiya, Saitama, Japan.
出版信息
Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. doi: 10.1016/j.bmcl.2003.11.005.
In a previous paper, we reported that an imidazole derivative 1 exhibited a potent inhibitory activity of 20-HETE synthase (1; IC(50) value of 5.7 nM), but this compound also exhibited little selectivity for cytochrome P450s (CYPs). We examined some derivatives of imidazole 1 which had an amino group on the side chain, and found that a dimethylaminohexyloxy derivative (3g; IC(50) value of 8.8 nM) showed potent and selective inhibitory activity.
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