Haskó György, Cronstein Bruce N
Department of Surgery, UMD-New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA.
Trends Immunol. 2004 Jan;25(1):33-9. doi: 10.1016/j.it.2003.11.003.
Although inflammatory and immunological reactions protect the host from invasion by microorganisms and eliminate debris at sites of tissue injury, they can also be responsible for significant tissue damage. Thus, regulatory mechanisms that limit damage from an overly exuberant immune response have evolved. It is increasingly apparent that adenosine, a purine nucleoside that is elaborated at injured and inflamed sites, has a central role in the regulation of inflammatory responses and in limiting inflammatory tissue destruction. Adenosine, called a 'retaliatory metabolite' because it is a regulatory autocoid that is generated as a result of cellular injury or stress, interacts with specific G protein-coupled receptors on inflammatory and immune cells to regulate their function. The effects of adenosine, acting at its receptors, on the functions of the cells that mediate innate immune responses, will be reviewed.
尽管炎症和免疫反应可保护宿主免受微生物入侵，并清除组织损伤部位的碎片，但它们也可能导致严重的组织损伤。因此，限制过度活跃的免疫反应造成损伤的调节机制已经进化出来。越来越明显的是，腺苷作为一种在损伤和炎症部位产生的嘌呤核苷，在调节炎症反应和限制炎症组织破坏方面发挥着核心作用。腺苷被称为“报复性代谢产物”，因为它是一种调节自分泌物质，由细胞损伤或应激产生，它与炎症和免疫细胞上的特定G蛋白偶联受体相互作用以调节其功能。本文将综述腺苷作用于其受体时，对介导先天免疫反应的细胞功能的影响。
