Kowalczuk Joanna, Tritt-Goc Jadwiga, Piślewski Narcyz
Institute of Molecular Physics, Polish Academy of Sciences, M. Smoluchowskiego 17, 60-179 Poznań, Poland.
Solid State Nucl Magn Reson. 2004 Jan;25(1-3):35-41. doi: 10.1016/j.ssnmr.2003.03.016.
Magnetic resonance imaging was used to study the behavior of the gel layer thickness in hydroxypropyl methyl cellulose (HPMC) matrices loaded with different amounts of soluble tetracycline hydrochloride. The time dependence of the diffusion front, effective T2, and proton-density analysis clearly indicates a Case II diffusion mechanism in the system composed of water solution of hydrochloric acid (pH = 2) and HPMC. The solvent penetration front was used to describe the swelling properties as well as the integrity of the HPMC matrices. The results show that the tetracycline hydrochloride decreases the resistance of the HPMC network structure against the movement of solvent molecules. On the other hand the swelling properties of the matrix increase with the amount of drug in the matrix.
采用磁共振成像技术研究了负载不同量可溶性盐酸四环素的羟丙基甲基纤维素（HPMC）基质中凝胶层厚度的变化情况。扩散前沿、有效T2以及质子密度分析随时间的变化清楚地表明，在由盐酸水溶液（pH = 2）和HPMC组成的体系中存在第二类扩散机制。溶剂渗透前沿用于描述HPMC基质的溶胀特性以及完整性。结果表明，盐酸四环素降低了HPMC网络结构对溶剂分子运动的阻力。另一方面，基质的溶胀特性随基质中药物量的增加而增强。
