Timoszyk Anna, Gdaniec Zofia, Latanowicz Lidia
Department of Biophysics, Institute of Biotechnology and Environmental Science, University of Zielona Góra, Podgórna 50, 65-246, Poland.
Solid State Nucl Magn Reson. 2004 Jan;25(1-3):142-5. doi: 10.1016/j.ssnmr.2003.03.023.
The paper reports the results of our study on the dynamics of model phospholipid membranes studied by 31P NMR spectroscopy. The 31P NMR spectra of multilamellar vesicles in temperatures below the main phase transition of PC are reported. The 31P NMR spectra revealed changes caused by an increase of the membrane fluidity when polysialic acid (polySia) was applied as a modifying agent. The presence of polySia in the external environment of the phospholipid vesicles changes the motional freedom in the region of phosphate group of lipids. Increase of polysialic acid concentration changes structural properties of a membrane by increasing its fluidity.
本文报道了我们通过31P核磁共振光谱研究模型磷脂膜动力学的研究结果。报道了在低于PC主相变温度下多层囊泡的31P核磁共振光谱。当将聚唾液酸（polySia）用作改性剂时，31P核磁共振光谱揭示了由膜流动性增加引起的变化。磷脂囊泡外部环境中聚唾液酸的存在改变了脂质磷酸基团区域的运动自由度。聚唾液酸浓度的增加通过增加膜的流动性来改变膜的结构性质。
