三元组分山梨醇单酯表面活性剂、油相和水相乳膏的形成与表征
Formation and characterization of three-component-sorbitan monoester surfactant, oil and water-creams.
作者信息
Korhonen Mirka, Hirvonen Jouni, Peltonen Leena, Antikainen Osmo, Yrjänäinen Laura, Yliruusi Jouko
机构信息
Pharmaceutical Production, Orion Corporation Orion Pharma, P.O. Box 425, FIN-20101 Turku, Finland.
出版信息
Int J Pharm. 2004 Jan 9;269(1):227-39. doi: 10.1016/j.ijpharm.2003.09.020.
The effect of molecular structure of four sorbitan monoester surfactants (sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate and sorbitan monooleate) on the formation of simple three-component creams is presented. Interfacial properties of the surfactants were determined using a du Nouy tensiometer and rheological properties of selected creams with oscillation stress sweep, creep recovery and viscosity tests. Depending on the composition, sorbitan monolaurate and sorbitan monooleate formed both o/w creams and w/o creams, while sorbitan monopalmitate and sorbitan monostearate formed only o/w creams. Sorbitan monostearate and sorbitan monopalmitate had the smallest cmc and A(cmc) values and they were the most effective surfactants in lowering the interfacial tension. These surfactants formed the most stable and elastic creams with clear linear viscoelastic regions and small compliance values. Sorbitan monolaurate and sorbitan monooleate formed viscous creams without elastic properties.
本文介绍了四种失水山梨醇单酯表面活性剂（失水山梨醇单月桂酸酯、失水山梨醇单棕榈酸酯、失水山梨醇单硬脂酸酯和失水山梨醇单油酸酯）的分子结构对简单三组分乳膏形成的影响。使用杜诺伊张力计测定表面活性剂的界面性质，并通过振荡应力扫描、蠕变恢复和粘度测试来测定所选乳膏的流变性质。根据组成不同，失水山梨醇单月桂酸酯和失水山梨醇单油酸酯既可以形成水包油型乳膏，也可以形成油包水型乳膏，而失水山梨醇单棕榈酸酯和失水山梨醇单硬脂酸酯仅形成水包油型乳膏。失水山梨醇单硬脂酸酯和失水山梨醇单棕榈酸酯的临界胶束浓度（cmc）和临界胶束浓度下的面积（A(cmc)）值最小，它们是降低界面张力最有效的表面活性剂。这些表面活性剂形成了最稳定且具有弹性的乳膏，具有清晰的线性粘弹性区域和较小的柔量值。失水山梨醇单月桂酸酯和失水山梨醇单油酸酯形成的是没有弹性特性的粘性乳膏。
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