Grant J, Cho J, Allen C
Department of Pharmaceutical Sciences, University of Toronto, 19 Russell Street, Toronto, Ontario, M5S 2S2 Canada.
Langmuir. 2006 Apr 25;22(9):4327-35. doi: 10.1021/la060017g.
The natural cationic polysaccharide chitosan was mixed with the nonionic surfactants sorbitan monolaurate, sorbitan monooleate, or sorbitan triooleate to produce a biopolymer-surfactant system with unique properties. The mixtures of chitosan and surfactant formed emulsion-like solutions and/or creams. The known properties of the components were considered (i.e., hydrophile-lipophile balance, molecular weight, structure, and density), and various physicochemical and rheological properties of the mixtures were measured. Specifically, the critical micelle concentration of the sorbitan esters in a chitosan solution was measured using both surface tension and fluorescence-based methods. The concentration-dependent morphologies of the aggregates within the chitosan-surfactant solutions were evaluated by optical microscopy and dynamic light scattering. A schematic depicting the possible molecular arrangement of chitosan and surfactant within the various formulations was produced from consideration of the experimental findings. The degree of interaction between chitosan and the individual surfactants was assessed by FTIR analysis. The rheological properties of the chitosan-surfactant emulsions were also investigated and found to be related to the observed morphologies. Overall, clear composition-property relationships were established for these chitosan-surfactant systems which have potential applications in the food and pharmaceutical industries.
天然阳离子多糖壳聚糖与非离子表面活性剂月桂山梨坦、油酸山梨坦或三油酸山梨坦混合，以制备具有独特性质的生物聚合物 - 表面活性剂体系。壳聚糖与表面活性剂的混合物形成了乳液状溶液和/或乳膏。考虑了各组分的已知性质（即亲水亲油平衡、分子量、结构和密度），并测量了混合物的各种物理化学和流变学性质。具体而言，使用表面张力法和荧光法测量了壳聚糖溶液中山梨醇酯的临界胶束浓度。通过光学显微镜和动态光散射评估了壳聚糖 - 表面活性剂溶液中聚集体的浓度依赖性形态。根据实验结果绘制了一个示意图，描述了壳聚糖和表面活性剂在各种配方中可能的分子排列。通过傅里叶变换红外光谱（FTIR）分析评估了壳聚糖与各表面活性剂之间的相互作用程度。还研究了壳聚糖 - 表面活性剂乳液的流变学性质，发现其与观察到的形态有关。总体而言，为这些壳聚糖 - 表面活性剂体系建立了明确的组成 - 性质关系，它们在食品和制药行业具有潜在应用。
