Kulesa Paul, Ellies Debra L, Trainor Paul A
Stowers Institute for Medical Research, Kansas City, Missouri, USA.
Dev Dyn. 2004 Jan;229(1):14-29. doi: 10.1002/dvdy.10485.
Cranial neural crest cells are a multipotent, migratory population that generates most of the cartilage, bone, connective tissue and peripheral nervous system in the vertebrate head. Proper neural crest cell patterning is essential for normal craniofacial morphogenesis and is highly conserved among vertebrates. Neural crest cell patterning is intimately connected to the early segmentation of the neural tube, such that neural crest cells migrate in discrete segregated streams. Recent advances in live embryo imaging have begun to reveal the complex behaviour of neural crest cells which involve intricate cell-cell and cell-environment interactions. Despite the overall similarity in neural crest cell migration between distinct vertebrates species there are important mechanistic differences. Apoptosis for example, is important for neural crest cell patterning in chick embryos but not in mouse, frog or fish embryos. In this paper we highlight the potential evolutionary significance of such interspecies differences in jaw development and evolution. Developmental Dynamics 229:14-29, 2004.
颅神经嵴细胞是一种多能性的迁移细胞群体，它生成脊椎动物头部的大部分软骨、骨骼、结缔组织和外周神经系统。适当的神经嵴细胞模式形成对于正常的颅面形态发生至关重要，并且在脊椎动物中高度保守。神经嵴细胞模式形成与神经管的早期节段化密切相关，使得神经嵴细胞以离散的、隔离的流迁移。活体胚胎成像的最新进展已开始揭示神经嵴细胞的复杂行为，其中涉及复杂的细胞 - 细胞和细胞 - 环境相互作用。尽管不同脊椎动物物种之间神经嵴细胞迁移总体相似，但存在重要的机制差异。例如，细胞凋亡对鸡胚胎中的神经嵴细胞模式形成很重要，但对小鼠、青蛙或鱼类胚胎则不然。在本文中，我们强调了这种种间差异在颌骨发育和进化中潜在的进化意义。《发育动力学》229:14 - 29，2004年。
