Hino K, Okuda M, Konishi T, Yamashita A, Kayano K, Kubota M, Yasunaga M, Fukumoto Y, Okita K
First Department of Internal Medicine, Yamaguchi University School of Medicine, Japan.
Liver. 1992 Dec;12(6):387-91. doi: 10.1111/j.1600-0676.1992.tb00593.x.
Using immunohistological methods, we studied the lymphoid follicles in liver biopsy specimens obtained from patients with chronic hepatitis C(CH-C) to determine whether they represented an autoimmune manifestation. In 84 specimens obtained by liver biopsy from 76 patients positive for C-100 antibody, we assessed the presence or absence of lymphoid follicles within the portal areas, and then compared the clinical and immunohistological profiles of the two groups defined on this basis. There were no significant differences in the serological and clinical profiles of the two groups, but the T4:T8 cell ratio within the portal areas differed significantly. A T4:T8 cell ratio > 1.0 was more common in the specimens containing lymphoid follicles. This finding resembled the distribution of T cell subpopulations in the portal areas of patients with autoimmune hepatitis, and suggested that lymphoid follicles may be worth investigating to elucidate the relationship between chronic hepatitis C and autoimmune hepatitis.
我们采用免疫组织学方法，研究了从慢性丙型肝炎（CH-C）患者获取的肝活检标本中的淋巴滤泡，以确定它们是否代表一种自身免疫表现。在对76例C-100抗体阳性患者进行肝活检获取的84份标本中，我们评估了门管区内淋巴滤泡的有无，然后比较了在此基础上定义的两组患者的临床和免疫组织学特征。两组患者的血清学和临床特征无显著差异，但门管区内的T4:T8细胞比值有显著差异。T4:T8细胞比值>1.0在含有淋巴滤泡的标本中更为常见。这一发现类似于自身免疫性肝炎患者门管区T细胞亚群的分布，提示淋巴滤泡可能值得研究，以阐明慢性丙型肝炎与自身免疫性肝炎之间的关系。
