Thomas Roman K, Re Daniel, Wolf Jürgen, Diehl Volker
Molecular Tumor Biology and Tumor Immunology group, Department I of Internal Medicine, University of Cologne, Germany.
Lancet Oncol. 2004 Jan;5(1):11-8. doi: 10.1016/s1470-2045(03)01319-6.
Classic Hodgkin's lymphoma is characterised by Hodgkin and Reed-Sternberg cells and in most cases are derived from germinal-centre B cells. Despite progress in basic research showing the natural precursor cells of Hodgkin's lymphoma, most key questions still remain unanswered. Among these are the basic transforming events, the involvement of oncogenic viruses, the mechanisms enabling Hodgkin and Reed Sternberg cells to resist apoptosis in the germinal centre, and the molecular causes of their characteristic phenotype. Beyond the disclosure of these issues, the detection of changes in gene expression, gene mutations, and chromosomal imbalances specific of Hodgkin's lymphoma are central to recent research that may allow one a better understanding of the natural history of this type of lymphoma.
经典型霍奇金淋巴瘤以霍奇金和里德-斯腾伯格细胞为特征，在大多数情况下起源于生发中心B细胞。尽管基础研究取得了进展，揭示了霍奇金淋巴瘤的天然前体细胞，但大多数关键问题仍未得到解答。其中包括基本的转化事件、致癌病毒的参与、使霍奇金和里德-斯腾伯格细胞在生发中心抵抗凋亡的机制，以及其特征性表型的分子原因。除了揭示这些问题外，检测霍奇金淋巴瘤特有的基因表达变化、基因突变和染色体失衡是近期研究的核心，这可能有助于人们更好地理解这种类型淋巴瘤的自然史。
