如何找到“缺失”的基因。

How to find "missing" genes.

作者信息

Gerlt John A

机构信息

Department of Biochemistry, University of Illinois, 415 Roger Adams Laboratory, 600 S Mathews Avenue, Urbana, IL 61801, USA.

出版信息

Chem Biol. 2003 Dec;10(12):1141-2. doi: 10.1016/j.chembiol.2003.12.008.

DOI:10.1016/j.chembiol.2003.12.008

PMID:14700618

Abstract

Assigning function to "new" proteins is frequently the rate-determining step for deciphering metabolic pathways and regulatory networks. Osterman and Begley break down this barrier by demonstrating that comparative analyses of microbial genomes is a powerful strategy for identifying pathway components.

摘要

为“新”蛋白质赋予功能通常是解读代谢途径和调控网络的限速步骤。奥斯特曼和贝格利通过证明微生物基因组的比较分析是识别途径成分的有力策略，打破了这一障碍。