Yamamoto H
Department of Surgical Oncology, National Cancer Center (NCCH), Tokyo, Japan.
Nihon Geka Gakkai Zasshi. 1992 Sep;93(9):1177-81.
Extended radical mastectomy (EXT) in 1, 137 patients with breast carcinoma was devised to eradicate all possible sites of local nodal metastases including internal mammary chain during the years 1962 through 1990. The tumors had to be mainly any T located in medial-half, central (excluding less 1.0 cm or histologic type with good prognosis) and T size measuring 3.0 cm or more in lateral-half. Prognostic outcomes were analysed by the presence or absence of nodes involved. The 10-year relapse free survival in patients with internal mammary node (IMN) only invaded and both axillary (AX) & IMN invaded were 47.8% and 40.1%, respectively. The incidence of relapse free survival at 10 years in relation to the number of positive AX and IMN indicated virtually favorable--1 positive: 71.4%, 2 or 3 positive: 61.3% and 4-9 positive: 53.7%. In our study, the frequency of IMN involvement calculated 24.1% from all quadrants of the breast. In comparison of nonrandomized series with medial-half and lateral-half tumors which involved positive IMN, comprising 95 and 28 patients of the total (n = 495), relapse free survivals at 15 years were 36.5% and 17.5%, respectively. It was presumed that the benefit of EXT would be found in medial-central tumors.
1962年至1990年间,对1137例乳腺癌患者实施了扩大根治性乳房切除术(EXT),旨在根除包括乳内链在内的所有可能发生局部淋巴结转移的部位。肿瘤主要为位于乳房内侧半、中央(不包括小于1.0 cm或预后良好的组织学类型)的任何T分期肿瘤,以及位于乳房外侧半、大小为3.0 cm或更大的T分期肿瘤。根据有无淋巴结受累情况分析预后结果。仅乳内淋巴结(IMN)受累和腋窝(AX)及IMN均受累的患者10年无复发生存率分别为47.8%和40.1%。10年无复发生存率与阳性AX和IMN数量的关系显示结果实际上较为乐观——1个阳性:71.4%,2或3个阳性:61.3%,4 - 9个阳性:53.7%。在我们的研究中,计算得出乳房各象限IMN受累的频率为24.1%。在对包括内侧半和外侧半肿瘤且IMN阳性的非随机系列病例进行比较时,内侧半肿瘤组95例和外侧半肿瘤组28例(共495例),15年无复发生存率分别为36.5%和17.5%。据推测,EXT的益处在内侧 - 中央肿瘤中会更为明显。