Kaneko M, Matsuda H, Nakano S, Asari S, Amino N
First Department of Surgery, Osaka University Medical School, Japan.
Nihon Geka Gakkai Zasshi. 1992 Sep;93(9):891-4.
To evaluate the effect of strategy to reduce the rate and outcome of MRSA infection, 940 patients with cardiovascular operations from 1988 to 1991 were analyzed in aspect of the infection rate and outcome per year. Prophylactics and treatments which have been done during recent four years were) to use the inhalation of vancomycin for MRSA carriers, to quit the intravenous administration of prophylactic antibiotics on third postoperative day, to limit medical staffs to treat the patient with MRSA infection, to choose the most susceptible combination of two antibiotics for MRSA in each patients by periodical checking of bacterial cultures. The percentages of patients with infection to all patients detected with MRSA per year were decreased from 80% in 1988, to 66% in 1989, 31% in 1990, and 30% in 1991. The numbers of patients who died from MRSA infection were 4 in 1988 and only one in 1989 and 1991. MRSA infection in cardiovascular surgery could be reduced by sophisticated methods of prophylactics and treatments.
为评估降低耐甲氧西林金黄色葡萄球菌（MRSA）感染率及改善感染结局的策略效果，对1988年至1991年期间940例行心血管手术的患者的年感染率及结局进行了分析。在最近四年中采取的预防和治疗措施包括：对MRSA携带者使用万古霉素吸入疗法；术后第三天停止预防性抗生素的静脉给药；限制医务人员治疗MRSA感染患者；通过定期检查细菌培养为每位患者选择最敏感的两种抗MRSA抗生素组合。每年检测出的MRSA感染患者占所有患者的百分比从1988年的80%降至1989年的66%、1990年的31%和1991年的30%。死于MRSA感染的患者人数在1988年为4例，在1989年和1991年仅为1例。通过完善的预防和治疗方法可降低心血管手术中的MRSA感染。
