Cahn Seth D, Herzog Andrew G, Pascual-Leone Alvaro
Laboratory for Magnetic Brain Stimulation, Behavioral Neurology, Neurology Department, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
J Clin Neurophysiol. 2003 Sep-Oct;20(5):371-4. doi: 10.1097/00004691-200309000-00009.
This investigation analyzed retrospective normative data from paired-pulse transcranial magnetic stimulation (PP TMS) studies to assess the effects of hemispheric laterality, gender, and handedness on cortical excitability. There were no significant differences between left and right hemisphere responses in either men or women. Likewise, there was no significant difference in findings between men and women, considering each hemisphere separately. There were no significant differences between right-handed individuals and nonright-handed individuals for left or right hemispheric responses in either men or women or for both genders combined. Nevertheless, large intersubject variance and past evidence of cortical excitability modulation by other factors, such as menstrual cycle phase and reproductive hormonal changes in women, suggest a need for further investigations into other potential factors that may contribute to the large variance among healthy individuals.
本研究分析了来自配对脉冲经颅磁刺激（PP TMS）研究的回顾性标准数据，以评估半球偏侧性、性别和利手对皮质兴奋性的影响。男性和女性的左右半球反应均无显著差异。同样，分别考虑每个半球时，男性和女性的研究结果也无显著差异。无论是男性还是女性，或者综合考虑两性，右利手个体和非右利手个体在左半球或右半球反应方面均无显著差异。然而，个体间差异较大，且过去有证据表明其他因素（如女性的月经周期阶段和生殖激素变化）可调节皮质兴奋性，这表明需要进一步研究其他可能导致健康个体间差异较大的潜在因素。
