Leeksma O C, Thomas L L, van der Lelie J, van Oers M H, von dem Borne A E, Goudsmit R
Department of Haematology, Academic Medical Centre, Amsterdam, Netherlands.
Neth J Med. 1992 Oct;41(3-4):143-8.
Six patients with acquired aplastic anaemia were treated with cyclosporine (5 mg/kg/day) either alone or in combination with corticosteroids. A favourable response was observed in 4, including 2 patients presenting with an absolute granulocyte count of less than 0.2 x 10(9)/l. The 6th patient showed no effect after 6 wk of therapy and was thereafter successfully treated with anti-thymocyte globulin (ATG). Side effects of cyclosporine therapy were minimal (maximum follow-up 20 months). Temporary discontinuation of the drug in 1 patient resulted in a relapse which responded to reinstitution of therapy. Our results indicate that cyclosporine may be an effective, well-tolerated agent in acquired aplastic anaemia even in previously untreated patients with severe neutropenia.
6例获得性再生障碍性贫血患者接受环孢素（5毫克/千克/天）单药治疗或联合皮质类固醇治疗。4例患者有良好反应，其中2例患者的绝对粒细胞计数低于0.2×10⁹/升。第6例患者在治疗6周后无效果，此后用抗胸腺细胞球蛋白（ATG）成功治疗。环孢素治疗的副作用极小（最长随访20个月）。1例患者暂时停药导致复发，重新治疗后有反应。我们的结果表明，环孢素在获得性再生障碍性贫血中可能是一种有效的、耐受性良好的药物，即使是在先前未治疗的严重中性粒细胞减少症患者中也是如此。
