通过铑催化的C-H键官能团化实现杂环的芳基化反应。
Arylation of heterocycles via rhodium-catalyzed C-H bond functionalization.
作者信息
Lewis Jared C, Wiedemann Sean H, Bergman Robert G, Ellman Jonathan A
机构信息
Center for New Directions in Organic Synthesis, Department of Chemistry, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA.
出版信息
Org Lett. 2004 Jan 8;6(1):35-8. doi: 10.1021/ol035985e.
PMID:14703344
Abstract
[reaction: see text] A new method for the rhodium-catalyzed arylation of a variety of heterocycles has been developed. The reaction provided moderate to good yields of the arylated products. A preliminary mechanistic investigation of this reaction revealed the intermediacy of an isolable N-heterocyclic carbene complex.
摘要
[反应：见正文] 已开发出一种用于铑催化多种杂环芳基化的新方法。该反应得到了中等至良好产率的芳基化产物。对该反应的初步机理研究揭示了一种可分离的N-杂环卡宾配合物的中间体。
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