Hayashi Yasuhide
Gunma Children's Medical Center, Kitatachibana, Gunma, Japan.
Int J Hematol. 2003 Dec;78(5):414-20. doi: 10.1007/BF02983813.
Recent advances in treatment have transformed childhood acute leukemias into curable diseases. However, 20% to 40% of acute leukemia patients still experience a relapse. Microarrays typically contain thousands of oligonucleotides or complementary DNAs and are rapidly becoming important research tools for the identification of novel classifications of leukemias and lymphomas. Microarray-based identification of several translocations has been performed in acute lymphoblastic leukemia (ALL), leading to the discovery of t(1;19), t(12;21), and 11q23 translocations, and in acute myeloid leukemia (AML), finding t(8;21), inv(16), and t(15;17). Correlations between gene expression profiles and clinical features have been reported in ALL and AML. Recently, it was reported that gene expression profiling can be used to predict the prognosis of childhood acute leukemia. In this report, the recent progress in microarray analysis of childhood acute leukemia is reviewed. Gene expression profiling provides new insights into the biological mechanisms of leukemogenesis and the prognosis of childhood acute leukemia.
治疗方面的最新进展已将儿童急性白血病转变为可治愈的疾病。然而，20%至40%的急性白血病患者仍会复发。微阵列通常包含数千个寡核苷酸或互补DNA，并且正迅速成为用于识别白血病和淋巴瘤新分类的重要研究工具。基于微阵列在急性淋巴细胞白血病（ALL）中已鉴定出几种易位，从而发现了t(1;19)、t(12;21)和11q23易位，在急性髓细胞白血病（AML）中发现了t(8;21)、inv(16)和t(15;17)。在ALL和AML中均已报道基因表达谱与临床特征之间的相关性。最近，有报道称基因表达谱分析可用于预测儿童急性白血病的预后。在本报告中，对儿童急性白血病微阵列分析的最新进展进行了综述。基因表达谱分析为白血病发生的生物学机制以及儿童急性白血病的预后提供了新的见解。
