Mahmutyazicioğlu Kamran, Turgut Mehmet
Department of Radiology, Inonu University Medical Faculty, 44300 Malatya, Turkey.
J Clin Ultrasound. 2004 Jan;32(1):24-8. doi: 10.1002/jcu.10215.
The aim of this study was to identify any changes in Doppler parameters in the thyroid arteries of pediatric patients with a clinical diagnosis of goiter living in an area where goiter is endemic.
In this prospective study, 20 pediatric patients with simple endemic goiter and 20 age-matched healthy subjects underwent sonographic examination. The resistance index (RI) and peak systolic velocity (PSV) on duplex sonography were measured from the inferior thyroid arteries, and the thyroid gland volume was recorded. Serum thyrotropin, free T3 hormone, and free T4 hormone levels were measured in both groups.
The mean thyroid volume (+/- standard deviation) was significantly higher in the patients than in the healthy subjects (7.2 +/- 1.4 ml versus 3.2 +/- 1.1 ml; p < 0.01). The mean RI values for the thyroid arteries were significantly lower in the patient than in the control group (0.58 versus 0.70, respectively; p < 0.05). The mean PSV of the thyroid arteries was significantly higher for the patients than for the healthy subjects (mean, 36.7 cm/second versus 18.3 cm/second, respectively; p < 0.05). There was no correlation between the Doppler parameters and any of the hormone levels evaluated.
In the arteries supplying the thyroid gland in a pediatric population, RIs were lower and PSVs higher in the patients with diffuse goiter than in the healthy control group. We discuss iodine deficiency as a possible mechanism for these changes.
本研究旨在确定在甲状腺肿流行地区临床诊断为甲状腺肿的儿科患者甲状腺动脉多普勒参数的任何变化。
在这项前瞻性研究中，20例单纯地方性甲状腺肿儿科患者和20例年龄匹配的健康受试者接受了超声检查。从甲状腺下动脉测量双功超声的阻力指数（RI）和收缩期峰值速度（PSV），并记录甲状腺体积。两组均测量血清促甲状腺激素、游离T3激素和游离T4激素水平。
患者的平均甲状腺体积（±标准差）显著高于健康受试者（7.2±1.4ml对3.2±1.1ml；p<0.01）。患者甲状腺动脉的平均RI值显著低于对照组（分别为0.58对0.70；p<0.05）。患者甲状腺动脉的平均PSV显著高于健康受试者（平均分别为36.7cm/秒对18.3cm/秒；p<0.05）。多普勒参数与所评估的任何激素水平之间均无相关性。
在儿科人群中，供应甲状腺的动脉中，弥漫性甲状腺肿患者的RI较低，PSV较高。我们讨论碘缺乏作为这些变化的一种可能机制。
