Yang Xinghao, Wang Guangji, Zhang Xiaotong
Pharmaceutical Research Center, Nanjing Normal University, Nanjing 210097, People's Republic of China.
J Pharm Sci. 2004 Feb;93(2):293-9. doi: 10.1002/jps.10564.
Chewing gums containing catechins were prepared by applying a novel solid dispersion and hot-melt fluid bed coating method. The effect of varying levels of Eudragit coating to the granules on the prolonged release of catechins from chewing gum was investigated. In vivo release profiles of catechins from the formulations were investigated to determine its release kinetics. Dissolution data were used as the primary basis for comparison. The equations with zero order, first-order, or square root of time release kinetics were used to fit data. The results showed that the releases of catechins from chewing gum were well extended with the growing coating level of Eudragit to the granules. The statistical analysis using nonlinear regression software suggested that the Higuchi equation describes the data better than others. The relatively high degree of fit using the Higuchi equation implies that the kinetic process is involved in the release of drug from the dosage form. A possible release mechanism based on this profile is presented in this report. This approach suggested the potential of using chewing gum as a promising controlled-release delivery system of drugs. The effect of polyvinyl acetates with different crosslinkings on the release profiles of catechins was also studied.
通过应用新型固体分散体和热熔流化床包衣法制备了含儿茶素的口香糖。研究了不同水平的Eudragit包衣对颗粒的影响，以及儿茶素从口香糖中的缓释情况。研究了制剂中儿茶素的体内释放曲线，以确定其释放动力学。溶出数据用作比较的主要依据。使用零级、一级或时间平方根释放动力学方程拟合数据。结果表明，随着Eudragit对颗粒包衣水平的增加，儿茶素从口香糖中的释放得到了很好的延长。使用非线性回归软件进行的统计分析表明，Higuchi方程比其他方程更能描述数据。使用Higuchi方程的相对高拟合度意味着动力学过程参与了药物从剂型中的释放。本报告提出了基于该曲线的可能释放机制。该方法表明了使用口香糖作为有前景的药物控释递送系统的潜力。还研究了不同交联度的聚醋酸乙烯酯对儿茶素释放曲线的影响。
