Kötter Ina, Vonthein Reinhard, Müller Claudia A, Günaydin Ilhan, Zierhut Manfred, Stübiger Nicole
Department of Internal Medicine II (Haematology, Oncology, Immunology, and Rheumatology), University Hospital, University of Tübingen, Tübingen, Germany.
J Rheumatol. 2004 Jan;31(1):133-9.
To evaluate the relationship between ethnic origin and manifestations of Behçet's disease (BD) in patients of German and Turkish origin living in Germany.
Between 1995 and 2000, 32 patients of German and 33 patients of Turkish origin living in Germany were evaluated for the entire spectrum of disease manifestations, disease severity, HLA associations, sex, age at disease manifestation, and time to diagnosis.
There were no statistically significant differences between German and Turkish patients. There was no association of sex or HLA-B51 with any manifestation of BD. The only significant difference between the 2 groups was the median time from the first manifestation of the disease to diagnosis, which was 0 years for the Turkish, but 3.5 years for the German patients (p = 0.0005). Additionally, 4 patients of German origin had been misdiagnosed as having spondyloarthropathy (SpA) before the final diagnosis of BD was made (12%). In comparison to Turkish patients living in Turkey (data from the literature), only 2 differences were found: one concerned the frequency of ocular involvement (lower in the patients in Turkey), and the other the male to female ratio, which was reported as 1.03:1 in Turkey, but 3.7:1 in Germany.
Our results do not favor an ethnic influence on the expression of BD. Environmental influences may be responsible for the higher frequency of ocular manifestations and the higher male to female ratio in patients living in Germany compared to those living in Turkey.
评估在德国生活的德国裔和土耳其裔患者中，种族起源与白塞病（BD）表现之间的关系。
在1995年至2000年期间，对32名德国裔和33名居住在德国的土耳其裔患者进行了评估，内容涵盖疾病表现的全谱、疾病严重程度、HLA相关性、性别、发病年龄以及诊断时间。
德国患者和土耳其患者之间无统计学显著差异。性别或HLA - B51与BD的任何表现均无关联。两组之间唯一的显著差异是从疾病首次出现到诊断的中位时间，土耳其患者为0年，而德国患者为3.5年（p = 0.0005）。此外，4名德国裔患者在最终确诊BD之前被误诊为脊柱关节病（SpA）（12%）。与生活在土耳其的土耳其患者（文献数据）相比，仅发现两点差异：一是眼部受累频率（土耳其患者较低），二是男女比例，土耳其报告为1.03:1，而德国为3.7:1。
我们的结果不支持种族对BD表达有影响。与生活在土耳其的患者相比，环境因素可能是德国患者眼部表现频率较高以及男女比例较高的原因。
