Wiśniewska R J, Kupryszewski G
Department of Pharmacology, Medical Academy, Białystok, Poland.
Pol J Pharmacol Pharm. 1992 May-Jun;44(3):281-7.
The effects of C-terminal unsulfated cholecystokinin octapeptide (CCK-8US) and its fragments C-terminal heptapeptide (CCK-7), C-terminal hexapeptide (CCK-6) and C-terminal pentapeptide (CCK-5) were studied on the arterial blood pressure and the isolated rat heart. CCK-8US had only slight hypertensive and no cardiac effects. CCK-5, CCK-6 and CCK-7 had no effect on the arterial blood pressure, the cardiac contraction amplitude and the heart rate. Only CCK-7 increased coronary outflow of the isolated rat heart. CCK-8US and C-terminal fragments; CCK-7 have little effect on the circulation of the rat.
研究了C末端无硫酸化的胆囊收缩素八肽（CCK - 8US）及其片段C末端七肽（CCK - 7）、C末端六肽（CCK - 6）和C末端五肽（CCK - 5）对动脉血压和离体大鼠心脏的影响。CCK - 8US仅有轻微的升压作用，对心脏无影响。CCK - 5、CCK - 6和CCK - 7对动脉血压、心脏收缩幅度和心率均无影响。只有CCK - 7增加离体大鼠心脏的冠脉流量。CCK - 8US及其C末端片段CCK - 7对大鼠循环系统影响较小。
