Pawlik W W, Gustaw P, Sendur R, Czarnobilski K, Hottenstein O D, Konturek S J
Institute of Physiology, Medical Academy, Kraków, Poland.
Pol J Pharmacol Pharm. 1992 May-Jun;44(3):289-98.
Peptide YY (PYY) is a recently discovered polypeptide which has been proposed as physiological inhibitor of pancreatic exocrine secretion. The purpose of this study was to evaluate the effects of exogenous PYY on pancreatic blood flow and oxygen consumption. In anesthetized dogs, the superior pancreatico-duodenal artery blood flow (SPBF), pancreatic microcirculatory blood flow (PBF) and pancreatic oxygen consumption (PVO2) were determined. Control values for SPBF, PVO2 and PBF averaged 43.3 ml/min, 1.8 ml/min, and 57.5 ml/min/100g of tissue, respectively. Following iv injection of PYY at doses of 200 and 400 pmol/kg the values of SPBF decreased by 12 +/- 1% and 22 +/- 2%, respectively. PVO2 was reduced by those doses of PYY by 9 +/- 1 and 17 +/- 3%, respectively. PBF was also reduced by 16 +/- 2 and 34 +/- 2%, respectively after those doses of PYY. Pretreatment with phentolamine reversed the blood flow and PVO2 responses to PYY because SPBF, PVO2 and PBF were significantly increased above the control level. However, after additional pretreatment with propranolol the pancreatic vascular and metabolic responses to PYY were abolished. The above pancreatic responses to PYY were also significantly reduced after acute adrenalectomy. The experimental data indicate that adrenergic pathway is involved in the mechanism of action of PYY on the pancreatic circulation.
肽YY（PYY）是一种最近发现的多肽，已被认为是胰腺外分泌的生理性抑制剂。本研究的目的是评估外源性PYY对胰腺血流和氧消耗的影响。在麻醉犬中，测定了胰十二指肠上动脉血流（SPBF）、胰腺微循环血流（PBF）和胰腺氧消耗（PVO2）。SPBF、PVO2和PBF的对照值分别平均为43.3 ml/min、1.8 ml/min和57.5 ml/min/100g组织。静脉注射剂量为200和400 pmol/kg的PYY后，SPBF值分别下降了12±1%和22±2%。这些剂量的PYY使PVO2分别降低了9±1%和17±3%。这些剂量的PYY后，PBF也分别降低了16±2%和34±2%。用酚妥拉明预处理可逆转对PYY的血流和PVO2反应，因为SPBF、PVO2和PBF显著高于对照水平。然而，在额外用普萘洛尔预处理后，胰腺对PYY的血管和代谢反应被消除。急性肾上腺切除术后，上述胰腺对PYY的反应也显著降低。实验数据表明，肾上腺素能途径参与了PYY对胰腺循环的作用机制。
