[The role of cholecystokinin receptors in the regulation of the circulation and oxygen consumption in the pancreas].

These studies were conducted to assess whether cholecystokinin (CCK) receptors play a role in the regulation of pancreatic vascular, metabolic and secretory responses. In anesthetized dogs, the superior pancreatico-duodenal artery blood flow (SPBF), pancreatic microcirculatory blood flow (PBF), pancreatic oxygen consumption, bicarbonate and protein output were determined. Control SPBF, PVO2 and PBF averaged 35.6 ml/min, 1.9 ml/min-100 g and 56 ml/min-100 g respectively. CCK-8 was infused intraarterially in doses of 12.5, 25 and 50 pM/kg-h. SPBF increased by 13, 21 and 43%, PBF increased by 17, 29 and 53% and PVO2 increased by 10, 15 and 38% respectively. With 10% bite + oleic acid placed in the intestinal lumen SPBF increased by 11%, PVO2 by 27% and PBF by 17% respectively. CCK and oleic acid + bile significantly increased pancreatic secretory activity. Pretreatment with a highly selective CCK receptor antagonist L-364 (1 mg/kg i.v.) abolished the circulatory, metabolic and secretory responses to CCK and significantly reduced these responses to luminal oleic acid and bile. These results suggest that the CCK receptors of the pancreas may be involved in the food-induced increases in the pancreatic blood flow, oxygen consumption and exocrine secretion.