Segal A, Loewengart G, Sudberg S
Arch Environ Health. 1978 Jan-Feb;33(1):33-5. doi: 10.1080/00039896.1978.10667305.
A personal monitoring badge has been developed for the detection of the direct-acting, alkylating carcinogen beta-propiolactone at atmospheric concentrations as low as 6 ppb for 24-hour and 0.6 ppm for 0.25-hour exposure. The method employs the trapping reagent p-nitrobenzyl pyridine (p-NBP) absorbed on a cellulose thin-layer chromatography (TLC) strip. Deoxyguanosine can be used in place of p-NBP, but its lower limit of detection is 60 ppb for 24-hour exposure. The authors also obtained positive results with the carcinogens bis (chloromethyl) ether, chloromethyl methyl ether, diepoxybutane, dimethylcarbamoyl chloride, ethyleneimine, and glycidaldehyde. In practice, the TLC strip is positioned in a filmbadge holder. The TLC strip monitoring badges are easy to prepare; they should encounter no resistance of personnel to their use since they are not cumbersome. Monitoring at the end of an exposure is simple and requires no expensive equipment or specialized personnel.
已开发出一种个人监测徽章，用于检测大气中低至6 ppb（24小时暴露）和0.6 ppm（0.25小时暴露）的直接作用烷基化致癌物β-丙内酯。该方法采用吸附在纤维素薄层色谱（TLC）条带上的捕获试剂对硝基苄基吡啶（p-NBP）。脱氧鸟苷可替代p-NBP使用，但其24小时暴露的检测下限为60 ppb。作者还使用致癌物双（氯甲基）醚、氯甲基甲基醚、1,4-二环氧丁烷、二甲基氨基甲酰氯、乙撑亚胺和缩水甘油醛获得了阳性结果。在实际应用中，TLC条带放置在薄膜徽章夹中。TLC条带监测徽章易于制备；由于它们不笨重，预计人员对其使用不会有抵触情绪。暴露结束时的监测很简单，不需要昂贵的设备或专业人员。
