Furrows S J, Hartley J C, Bell J, Silver N, Losseff N, Stevenson S, Chapman M, Thompson E J, Ridgway G L, Giovannoni G
Microbiology Department, University College London Hospitals, London WC1E 6DB, UK.
J Neurol Neurosurg Psychiatry. 2004 Jan;75(1):152-4.
Chlamydophila pneumoniae has been postulated as an aetiological agent in the pathophysiology of multiple sclerosis. Previous studies show conflicting results.
To investigate patients with multiple sclerosis and other neurological diseases for evidence of past or present infection with C pneumoniae.
19 patients with multiple sclerosis and 29 with other neurological diseases were studied. Evidence was sought for past or present infection with C pneumoniae using polymerase chain reaction (PCR) and cell culture of cerebrospinal fluid (CSF), and enzyme linked immunosorbent assay and microimmunofluorescence of serum.
C pneumoniae was grown from the CSF of one patient with multiple sclerosis. PCR was negative in all cases. Anti-chlamydial antibodies were detected in the same proportion in each group.
This study does not support the theory of an association between C pneumoniae and multiple sclerosis.
肺炎衣原体被认为是多发性硬化症病理生理学中的一种病原体。以往研究结果相互矛盾。
调查多发性硬化症患者和其他神经系统疾病患者过去或现在感染肺炎衣原体的证据。
对19例多发性硬化症患者和29例其他神经系统疾病患者进行研究。采用聚合酶链反应（PCR）和脑脊液（CSF）细胞培养，以及血清酶联免疫吸附测定和微量免疫荧光法，寻找过去或现在感染肺炎衣原体的证据。
1例多发性硬化症患者的脑脊液中培养出肺炎衣原体。所有病例PCR均为阴性。每组中检测到抗衣原体抗体的比例相同。
本研究不支持肺炎衣原体与多发性硬化症之间有关联的理论。
