Margery J, Ferroir J-P, Epaud C, Martin C, Milleron B
Unité Fonctionnelle d'Oncologie Pulmonaire, Service de Pneumologie (Pr C. Mayaud), Hôpital Tenon, 4, rue de la Chine, 75020 Paris.
Rev Pneumol Clin. 2003 Nov;59(5 Pt 1):321-4.
Opsoclonus-myoclonus syndrome was observed in a patient treated for small-cell lung cancer. Opsoclonus presented as anarchic involuntary eye movements associated with myoclonies of the limbs and trunk. Opsoclonus-myoclonus is exceptional and a specific expression among several paraneoplastic manifestations described in small-cell lung cancer. These manifestations develop late after diagnosis of cancer. Presence of anti-neuronal antibodies in the serum (inconstant) is a factor of very poor prognosis.
在一名接受小细胞肺癌治疗的患者中观察到眼阵挛-肌阵挛综合征。眼阵挛表现为与四肢和躯干肌阵挛相关的无规律不自主眼球运动。眼阵挛-肌阵挛在小细胞肺癌所描述的几种副肿瘤表现中较为罕见且具有特异性。这些表现在癌症诊断后较晚出现。血清中抗神经元抗体的存在(不恒定)是预后极差的一个因素。