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小细胞肺癌合并眼阵挛-肌阵挛综合征

[Small cell lung cancer complicated by opsoclonus myoclonus syndrome].

作者信息

Iwata Toshiyuki, Yokomura Ichiro, Ohsugi Shuji, Uesaka Ayuko, Sekiguchi Kenji, Nishio Akira

机构信息

Department of Respiratory Medicine, Shakaihoken Kobe Central Hospital.

出版信息

Nihon Kokyuki Gakkai Zasshi. 2009 Nov;47(11):1046-50.

Abstract

Opsoclonus myoclonus syndrome, one of the paraneoplastic neurological syndromes involving several neurological symptoms that result from "remote effects" of cancer, is a rare disease characterized by opsoclonus, cerebellar ataxia and myoclonus of the trunk and extremities. A 53-year-old man was admitted with dizziness and difficulty walking. Medical examinations led to a diagnosis of opsoclonus myoclonus syndrome. CT scans showed mediastinal and cervical lymphadenopathy, and a diagnosis of small cell lung cancer was made. Steroid therapy and chemotherapy (carboplatin + etoposide) produced significant improvement in the neurological symptoms.

摘要

眼阵挛-肌阵挛综合征是一种副肿瘤性神经综合征,由癌症的“远隔效应”导致多种神经症状,是一种罕见疾病,其特征为眼阵挛、小脑共济失调以及躯干和四肢的肌阵挛。一名53岁男性因头晕和行走困难入院。医学检查诊断为眼阵挛-肌阵挛综合征。CT扫描显示纵隔和颈部淋巴结肿大,诊断为小细胞肺癌。类固醇疗法和化疗(卡铂+依托泊苷)使神经症状有显著改善。

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