c-Abl和Bcr-Abl酪氨酸激酶的调控
Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
作者信息
Hantschel Oliver, Superti-Furga Giulio
机构信息
Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
出版信息
Nat Rev Mol Cell Biol. 2004 Jan;5(1):33-44. doi: 10.1038/nrm1280.
DOI:10.1038/nrm1280
PMID:14708008
Abstract
The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr-Abl fusion protein, causes certain human leukaemias. Recent insights into the structure and regulation of the c-Abl and Bcr-Abl tyrosine kinases have changed the way we look at these enzymes.
摘要
原型非受体酪氨酸激酶c-Abl参与多种细胞过程。其致癌对应物Bcr-Abl融合蛋白会引发某些人类白血病。最近对c-Abl和Bcr-Abl酪氨酸激酶的结构与调控的深入了解，改变了我们看待这些酶的方式。
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