Zhao Q, Dahlin L B, Kanje M
Department of Hand Surgery, General Hospital, Malmö, Sweden.
Scand J Plast Reconstr Surg Hand Surg. 1992;26(3):265-70. doi: 10.3109/02844319209015269.
Reinnervation of the gastrocnemius and anterior tibial muscles was assessed by measurements of tetanic force after repair of sciatic nerves with Y-shaped or X-shaped silicone tubes in rats. The transsected proximal stump of either the tibial or the peroneal fascicle was introduced into the opening of a Y-shaped silicone tube, or both fascicles were introduced into an X-shaped tube. The distal tibial and peroneal fascicles were inserted into the distal outlets of the tubes leaving a gap of 4 mm between proximal and distal stumps. In the X-shaped tubes the proximal inserts were placed opposite or adjacent to their respective distal parts. Sixteen weeks later reinnervation was evaluated by measurements of tetanic force of the gastrocnemius and anterior tibial muscles after electrical stimulation of the fascicles. There was preferential reinnervation in both types of tubes. In Y-shaped tubes about 90% of the tetanic force could be recorded from both muscles after stimulation of the peroneal and tibial fascicles, respectively. Recovery was lower in the X-shaped tubes, amounting to about 75%. Contractions evoked by misrouted fibres were similar (roughly 40%) in both models. We conclude that motor axons preferentially, but not exclusively, selected a path to reinnervate their original target muscle.
通过在大鼠坐骨神经修复中使用 Y 形或 X 形硅胶管后测量强直收缩力来评估腓肠肌和胫前肌的神经再支配情况。将胫神经或腓总神经束的切断近端残端插入 Y 形硅胶管的开口处，或者将两个神经束都插入 X 形管中。将胫神经和腓总神经的远端束插入管的远端出口，近端和远端残端之间留出 4 毫米的间隙。在 X 形管中，近端插入物与其各自的远端部分相对或相邻放置。16 周后，通过对神经束进行电刺激后测量腓肠肌和胫前肌的强直收缩力来评估神经再支配情况。两种类型的管中均存在优先神经再支配现象。在 Y 形管中，分别刺激腓总神经和胫神经束后，两块肌肉均可记录到约 90%的强直收缩力。X 形管中的恢复率较低，约为 75%。两种模型中由误行纤维引起的收缩相似（约 40%）。我们得出结论，运动轴突优先但并非唯一地选择一条路径来重新支配其原来的目标肌肉。
