Tuominen L, Strengell L
Division of Plastic Surgery, Töölö Hospital, University Central Hospital, Helsinki, Finland.
Scand J Plast Reconstr Surg Hand Surg. 1992;26(3):287-92. doi: 10.3109/02844319209015273.
The clinical and histological characteristics of palmar, plantar, and subungual melanomas treated in the division of plastic surgery of Helsinki University Hospital between 1970 and 1984 were analysed. The peak incidence was during the seventh decade of life, and the mean delay between the onset of symptoms and the diagnosis was one year. The delay was as much the fault of the physician as of the patient. The observed and relative five-year-survival rates for all 31 patients were 60% and 67%, and the 10-year-survival rates 39% and 49%, respectively. There were 15 cases of the acral lentiginous subtype, and the observed and relative five-year-survival rates were 65% and 71%, and the 10-year-survival rates 48% and 64%, respectively. For the nodular melanomas (n = 11) the survival rates were 53% and 60%, and 39% and 53%, respectively. For the three superficial spreading melanomas they were 50% and 52%, and 25% and 28%, respectively. Microstaging criteria (Breslow and Clark) were both good prognostic indicators. The series was too small for multivariate analysis.
对1970年至1984年间在赫尔辛基大学医院整形外科接受治疗的手掌、足底和甲下黑色素瘤的临床和组织学特征进行了分析。发病高峰出现在70岁年龄段,症状出现到诊断的平均延迟时间为1年。这种延迟既是医生的过错,也是患者的过错。31例患者的观察到的五年生存率和相对五年生存率分别为60%和67%,十年生存率分别为39%和49%。有15例肢端雀斑样痣亚型,观察到的五年生存率和相对五年生存率分别为65%和71%,十年生存率分别为48%和64%。结节性黑色素瘤(n = 11)的生存率分别为53%和60%,以及39%和53%。对于3例浅表扩散性黑色素瘤,生存率分别为50%和52%,以及25%和28%。微分期标准(Breslow和Clark)都是良好的预后指标。该系列样本量太小,无法进行多变量分析。