Melo Marco E F, Stevens David B, Sercarz Eli E, Gabaglia Claudia Raja
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095-1489, USA.
J Autoimmun. 2004 Feb;22(1):13-20. doi: 10.1016/j.jaut.2003.09.005.
Nasal installation or oral feeding of antigens can alter the subsequent immune response in animals and humans. Most mucosal treatments with antigens tend to down-regulate disease, inducing full tolerance or immune deviation; however, priming has also been reported. We evaluated the course of experimental autoimmune encephalomyelitis (EAE) in (SJL x B10.PL)F1 mice after nasal instillation of myelin basic protein. There was a tendency towards exacerbation of subsequent disease in animals if they were nasally exposed to gpMBP during the neonatal period (first week of life), compared to exposure during adulthood. Later, at 11 months of age, this tendency to exacerbate disappeared. Our results suggest that mucosal exposure during early life may regularly modulate the anti-self immune response upwards in individuals genetically predisposed to autoimmune diseases.
鼻腔接种或口服抗原可改变动物和人类随后的免疫反应。大多数用抗原进行的黏膜治疗往往会下调疾病，诱导完全耐受或免疫偏离；然而，也有引发免疫反应的报道。我们评估了在（SJL×B10.PL）F1小鼠鼻腔滴注髓鞘碱性蛋白后实验性自身免疫性脑脊髓炎（EAE）的病程。与成年期暴露相比，如果动物在新生期（出生后第一周）鼻腔暴露于糖蛋白化髓鞘碱性蛋白（gpMBP），随后疾病有加重的趋势。后来，在11个月大时，这种加重的趋势消失了。我们的结果表明，在生命早期的黏膜暴露可能会定期上调那些具有自身免疫性疾病遗传易感性个体的自身免疫反应。
