Dodd Jodie M, Robinson Jeffrey S, Crowther Caroline A, Chan Annabelle
Department of Obstetrics and Gynecology, University of Adelaide, North Adelaide, Australia.
Am J Obstet Gynecol. 2003 Dec;189(6):1731-6. doi: 10.1016/s0002-9378(03)00854-8.
The purpose of this study was to determine the effect of maternal factors associated with impaired placental function on stillbirth and neonatal death rates in South Australia.
From 1991 to 2000, the South Australian Pregnancy Outcome Unit's population database was searched to identify stillbirths and neonatal deaths in women with maternal medical conditions during pregnancy and in twin and singleton pregnancies.
Women with hypertension and carbohydrate intolerance and who smoked during pregnancy had an increased risk of stillbirth. Women with twin pregnancies had a significantly higher stillbirth rate than for singletons at each week of gestational age. An increase in stillbirth rate at later gestations was seen with singletons, with a similar trend in twins but rising from 36 weeks' gestation.
There is a clinical correlation between maternal factors associated with impaired placental function and increased risk of stillbirth, suggesting that intrauterine fetal death represents the mortality end point in a spectrum of intrauterine hypoxia.
本研究旨在确定南澳大利亚州与胎盘功能受损相关的母体因素对死产率和新生儿死亡率的影响。
1991年至2000年期间，检索了南澳大利亚州妊娠结局单位的人口数据库，以确定孕期患有母体疾病的妇女以及双胎和单胎妊娠中的死产和新生儿死亡情况。
患有高血压、糖耐量异常且孕期吸烟的妇女死产风险增加。双胎妊娠妇女在每个孕周的死产率均显著高于单胎妊娠妇女。单胎妊娠在孕晚期死产率增加，双胎妊娠有类似趋势，但从孕36周开始上升。
与胎盘功能受损相关的母体因素与死产风险增加之间存在临床关联，提示宫内胎儿死亡代表了一系列宫内缺氧中的死亡终点。
