Dawson E L, Hardy T G, Collin J R, Lee J P
Moorfields Eye Hospital, City Road, London EC1V 2PD, England, U.K.
Strabismus. 2003 Sep;11(3):173-7. doi: 10.1076/stra.11.3.173.16645.
A retrospective review was carried out of 204 patients with blepharophimosis, (blepharo) ptosis and epicanthus inversus syndrome (BPES). Of these, 94 (46%) had an autosomal dominant family history of BPES. Forty (20%) had manifest strabismus. Of these, 28 (70%) had esotropia, 10 (25%) had exotropia and 2 (5%) had hypertropia. Twelve (6%) patients had nystagmus. Seventy (34%) patients had a significant refractive error requiring spectacles. Twenty-one (30%) of these patients had anisometropic hypermetropia and 24 (34%) had anisometropic myopia. Forty-three patients had bilateral amblyopia and 40 had unilateral amblyopia, with 26 (65%) of these undergoing occlusion treatment. Of these, 14 had strabismus and refractive error, 7 refractive error only, 2 strabismus only and 3 neither refractive error nor strabismus. We conclude that there is a higher incidence of strabismus and refractive error in patients with BPES than in the normal population.
对204例睑裂狭小、（睑）下垂和内眦赘皮综合征（BPES）患者进行了回顾性研究。其中，94例（46%）有BPES的常染色体显性家族史。40例（20%）有明显斜视。其中，28例（70%）为内斜视，10例（25%）为外斜视，2例（5%）为上斜视。12例（6%）患者有眼球震颤。70例（34%）患者有需要配镜的明显屈光不正。其中，21例（30%）为屈光参差性远视，24例（34%）为屈光参差性近视。43例患者有双侧弱视，40例有单侧弱视，其中26例（65%）接受了遮盖治疗。其中，14例有斜视和屈光不正，7例仅有屈光不正，2例仅有斜视，3例既无屈光不正也无斜视。我们得出结论，BPES患者斜视和屈光不正的发生率高于正常人群。
