Misra R, Hissaria P, Tandon Vini, Aggarwal Amita, Krishnani N, Dabadghao S
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India 226 014.
J Assoc Physicians India. 2003 Sep;51:859-62.
Primary Sjogren's syndrome (SS) is rarely reported from India. We have studied the clinical spectrum and immunological profile of patients with primary SS.
A prospective analysis of patients with primary Sjogren's syndrome fulfilling San Francisco criteria, seen at our clinic in the last 10 years was carried out.
The study included 26 patients, 21 being women. The presenting symptoms included dry eyes, dry mouth, and arthritis/arthralgia. Extra-glandular manifestations were glomerulonephritis, vasculitis, renal tubular acidosis and peripheral neuropathy. The important laboratory abnormalities were hypergammaglobulinaemia (16/20), antinuclear antibodies (18/26), anti-La (11/19) and anti-Ro (10/19). Minor salivary gland provided a definitive diagnosis in 16/26 (60%).
The prevalence of primary Sjogren's syndrome is rare even in tertiary care rheumatology clinics. The clinical and immunological profile as seen here is similar to that reported in Western countries.
印度原发性干燥综合征（SS）的报道很少。我们对原发性SS患者的临床谱和免疫特征进行了研究。
对过去10年在我们诊所就诊的符合旧金山标准的原发性干燥综合征患者进行前瞻性分析。
该研究纳入26例患者，其中21例为女性。主要症状包括眼干、口干和关节炎/关节痛。腺外表现为肾小球肾炎、血管炎、肾小管酸中毒和周围神经病变。重要的实验室异常包括高球蛋白血症（16/20）、抗核抗体（18/26）、抗La（11/19）和抗Ro（10/19）。小唾液腺活检在16/26（60%）的患者中提供了明确诊断。
即使在三级医疗风湿病诊所，原发性干燥综合征的患病率也很低。这里观察到的临床和免疫特征与西方国家报道的相似。
