Shetty Shrimati, Ghosh Kanjaksha, Mohanty Dipika
Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai 400 012, India.
J Assoc Physicians India. 2003 Sep;51:916-8.
With the advent of molecular biology techniques prenatal diagnosis in haemophilia A is generally being performed by first trimester chorionic villus sampling followed by the DNA analysis using various polymorphic markers of factor VIII gene. Here we report antenatal diagnosis in a haemophilia A family performed in the second trimester by measuring both factor VIII:C and factor VIII:Ag in the fetal blood sample.
随着分子生物学技术的出现，甲型血友病的产前诊断一般通过孕早期绒毛取样，随后使用因子VIII基因的各种多态性标记进行DNA分析来进行。在此，我们报告一个甲型血友病家族在孕中期通过检测胎儿血样中的因子VIII:C和因子VIII:Ag进行的产前诊断。
