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Use of RNA yeast polymerase II mutants in studying transcription elongation.

作者信息

Reines Daniel

机构信息

Department of Biochemistry, Emory University School of Medicine, 4023 Rollins Research Center, Atlanta, Georgia 30322, USA.

出版信息

Methods Enzymol. 2003;371:284-92. doi: 10.1016/S0076-6879(03)71021-0.

DOI:10.1016/S0076-6879(03)71021-0
PMID:14712708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3367478/
Abstract
摘要

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Use of RNA yeast polymerase II mutants in studying transcription elongation.RNA酵母聚合酶II突变体在转录延伸研究中的应用。
Methods Enzymol. 2003;371:284-92. doi: 10.1016/S0076-6879(03)71021-0.
2
Saccharomyces cerevisiae transcription elongation mutants are defective in PUR5 induction in response to nucleotide depletion.酿酒酵母转录延伸突变体在响应核苷酸耗竭时PUR5诱导方面存在缺陷。
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Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast.酵母药物敏感型转录延伸突变体中肌苷一磷酸脱氢酶基因的调控及其过表达
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4
Large-scale screening of yeast mutants for sensitivity to the IMP dehydrogenase inhibitor 6-azauracil.大规模筛选对肌苷酸脱氢酶抑制剂6-氮尿嘧啶敏感的酵母突变体。
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6
RNA polymerase II subunit Rpb9 regulates transcription elongation in vivo.
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Rad26, the transcription-coupled repair factor in yeast, is required for removal of stalled RNA polymerase-II following UV irradiation.酵母中的转录偶联修复因子 Rad26，在 UV 照射后移除停滞的 RNA 聚合酶 II 是必需的。
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Mutations in the second largest subunit of RNA polymerase II cause 6-azauracil sensitivity in yeast and increased transcriptional arrest in vitro.RNA聚合酶II第二大亚基的突变会导致酵母对6-氮尿嘧啶敏感，并在体外增加转录停滞。
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Analysis of gene induction and arrest site transcription in yeast with mutations in the transcription elongation machinery.对转录延伸机制存在突变的酵母中的基因诱导和终止位点转录的分析。
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Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo.体内RNA聚合酶II催化活性改变带来的广泛且意想不到的后果。
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Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling.Eaf5/7/3 形成一个功能上独立的 NuA4 亚基模块，与 RNA 聚合酶 II 偶联的核小体重组相关联。
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Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins.Rtr1是一类新型RNA聚合酶II结合蛋白家族在酿酒酵母中的同源物。
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Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast.肌苷-5'-单磷酸脱氢酶基因在赋予酵母霉酚酸抗性和鸟嘌呤原养型方面的功能差异。
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本文引用的文献

1
Large-scale screening of yeast mutants for sensitivity to the IMP dehydrogenase inhibitor 6-azauracil.大规模筛选对肌苷酸脱氢酶抑制剂6-氮尿嘧啶敏感的酵母突变体。
Yeast. 2004 Feb;21(3):241-8. doi: 10.1002/yea.1068.
2
Biochemical genomics approach to map activities to genes.将活性映射到基因的生化基因组学方法。
Methods Enzymol. 2002;350:546-59. doi: 10.1016/s0076-6879(02)50984-8.
3
Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid.筛选酵母“破坏基因组”以寻找影响对免疫抑制药物霉酚酸抗性的突变体。
J Biol Chem. 2002 Jul 26;277(30):27036-44. doi: 10.1074/jbc.M111433200. Epub 2002 May 16.
4
Nucleosome remodeling induced by RNA polymerase II: loss of the H2A/H2B dimer during transcription.RNA聚合酶II诱导的核小体重塑：转录过程中H2A/H2B二聚体的丢失。
Mol Cell. 2002 Mar;9(3):541-52. doi: 10.1016/s1097-2765(02)00472-0.
5
The Paf1 complex physically and functionally associates with transcription elongation factors in vivo.Paf1复合物在体内与转录延伸因子在物理和功能上相互关联。
EMBO J. 2002 Apr 2;21(7):1764-74. doi: 10.1093/emboj/21.7.1764.
6
Requirement for yeast RAD26, a homolog of the human CSB gene, in elongation by RNA polymerase II.酵母RAD26（人类CSB基因的同源物）在RNA聚合酶II延伸过程中的需求。
Mol Cell Biol. 2001 Dec;21(24):8651-6. doi: 10.1128/MCB.21.24.8651-8656.2001.
7
Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast.酵母药物敏感型转录延伸突变体中肌苷一磷酸脱氢酶基因的调控及其过表达
J Biol Chem. 2001 Aug 31;276(35):32905-16. doi: 10.1074/jbc.M105075200. Epub 2001 Jul 5.
8
Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.遗传学证据支持酵母CCR4-NOT复合物在转录延伸中发挥作用。
Genetics. 2001 Jun;158(2):627-34. doi: 10.1093/genetics/158.2.627.
9
The tandem affinity purification (TAP) method: a general procedure of protein complex purification.串联亲和纯化（TAP）方法：蛋白质复合物纯化的通用程序。
Methods. 2001 Jul;24(3):218-29. doi: 10.1006/meth.2001.1183.
10
The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II.蛋白酶体的19S调节颗粒是RNA聚合酶II高效转录延伸所必需的。
Mol Cell. 2001 May;7(5):981-91. doi: 10.1016/s1097-2765(01)00250-7.