Khadadah M E, Onadeko B O, Abul A T, Behbehan N A, Cerna M, Cherian J M, Adesina O, Maradni N, Jayakrishnan B
Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.
Int J Clin Pract. 2003 Dec;57(10):879-84.
Though common, the exact incidence and clinical pattern of idiopathic pulmonary fibrosis (IPF) in Gulf countries are not known. The results of a four-year prospective study undertaken in two tertiary hospitals in Kuwait are presented. The mean age at diagnosis of the 52 patients studied was 55.40 +/- 11.87 years. Thirty-two (61.5%) patients were male and 22 (42.3%) were smokers. The mean duration of symptoms at diagnosis was 2.1 +/- 0.92 years. Digital clubbing was found in 34 (65%) patients. The mean FVC, TLC and TLCO were 57%, 64.4% and 55% of predicted normal, respectively. The FVC value showed a significant difference between smokers and non-smokers (p < 0.05). HRCT findings were abnormal in all patients. Typical histological and high-resolution computed tomography findings of usual interstitial pneumonia, desquamative interstitial pneumonia and non-specific interstitial pneumonia were observed. This study revealed that IPF is prevalent in Kuwait, with patterns showing some similarities to those established elsewhere. The response to treatment was not encouraging, especially in the usual interstitial pneumonia subtype.
尽管特发性肺纤维化（IPF）很常见，但海湾国家IPF的确切发病率和临床模式尚不清楚。本文介绍了在科威特两家三级医院进行的一项为期四年的前瞻性研究结果。所研究的52例患者诊断时的平均年龄为55.40±11.87岁。32例（61.5%）患者为男性，22例（42.3%）为吸烟者。诊断时症状的平均持续时间为2.1±0.92年。34例（65%）患者出现杵状指。平均用力肺活量（FVC）、肺总量（TLC）和一氧化碳弥散量（TLCO）分别为预测正常值的57%、64.4%和55%。吸烟者和非吸烟者的FVC值存在显著差异（p<0.05）。所有患者的高分辨率CT（HRCT）检查结果均异常。观察到了普通型间质性肺炎、脱屑性间质性肺炎和非特异性间质性肺炎的典型组织学和高分辨率CT表现。这项研究表明，IPF在科威特很普遍，其模式与其他地方已确定的模式有一些相似之处。治疗反应并不乐观，尤其是在普通型间质性肺炎亚型中。
