Jonzon A, Norsted T, Sedin G
Department of Pediatrics, University Hospital, University of Uppsala, Sweden.
Ups J Med Sci. 1992;97(2):115-26. doi: 10.3109/03009739209179288.
This study was made to determine how oscillations superimposed on intermittent positive pressure ventilation (IPPV) influence the arterial blood gases, pH and the airway pressures during adequate alveolar ventilation i.e. at inhibition of inspiratory activity, before and after experimentally induced lung injury in the anaesthetized cat. Two IPPV frequencies were studied. The lung was injured by instillation of xanthine oxidase into the upper airways during IPPV. The peak, mean and end-expiratory intrapleural and airway (intratracheal) pressures at two levels were measured and the arterial blood gases and pH were determined at inhibition of inspiratory activity with and without superimposition of oscillations on the ventilatory pattern. Before lung injury, superimposed oscillations lowered the airway pressures only at an IPPV rate of 15 breaths per minute (b.p.m.). After lung injury, such oscillations increased the airway pressures only at 15 b.p.m. The airway pressures were always lower at 60 than at 15 b.p.m.
本研究旨在确定在麻醉猫实验性诱导肺损伤前后，叠加于间歇正压通气（IPPV）的振荡如何在充分肺泡通气期间（即吸气活动受抑制时）影响动脉血气、pH值和气道压力。研究了两种IPPV频率。在IPPV期间，通过向上气道滴注黄嘌呤氧化酶造成肺损伤。测量了两个水平的峰值、平均和呼气末胸膜腔内压及气道（气管内）压，并在吸气活动受抑制且通气模式有或无振荡叠加的情况下测定动脉血气和pH值。肺损伤前，叠加振荡仅在IPPV频率为每分钟15次呼吸（b.p.m.）时降低气道压力。肺损伤后，此类振荡仅在15 b.p.m.时增加气道压力。气道压力在60 b.p.m.时始终低于15 b.p.m.时。
