Mioduszewska Barbara, Jaworski Jacek, Kaczmarek Leszek
Nencki Institute, Warsaw, Poland Warsaw Agriculture University, Veterinary School, Warsaw, Poland.
J Neurochem. 2003 Dec;87(6):1313-20. doi: 10.1046/j.1471-4159.2003.02116.x.
The acronym ICER (inducible cAMP early repressor) refers to a group of four proteins produced from the CREM/ICER gene due to use of an internal promoter (P2) placed in an intron of the CREM (cAMP responsive element modulator) gene. The ICER proteins contain DNA binding/leucine zipper domains that make them endogenous inhibitors of transcription driven by CREB (cAMP responsive element binding protein) and its cognates, CREM and ATF-1 (activating transcription factor-1). ICER expression is inducible in the brain and in neuronal culture by a variety of stimuli. As a CREB antagonist, ICER appears to be of pivotal importance in neuronal plasticity and programmed cell death.
首字母缩略词ICER（诱导型cAMP早期阻遏物）指的是由于使用位于CREM（cAMP反应元件调节因子）基因内含子中的内部启动子（P2），从CREM/ICER基因产生的一组四种蛋白质。ICER蛋白包含DNA结合/亮氨酸拉链结构域，这使它们成为由CREB（cAMP反应元件结合蛋白）及其同源物CREM和ATF-1（激活转录因子-1）驱动的转录的内源性抑制剂。ICER表达可通过多种刺激在大脑和神经元培养物中被诱导。作为一种CREB拮抗剂，ICER似乎在神经元可塑性和程序性细胞死亡中起关键作用。
