Wahl Sharon M, Chen Wanjun
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4352, USA.
Immunol Res. 2003;28(3):167-79. doi: 10.1385/IR:28:3:167.
A balance between an adequate immune response to an antigen or pathogen and tolerance is a prerequisite for normal immune homeostasis and the well-being of the host. In this complex self-regulation, multiple mechanisms have been implicated as contributing to the immune tolerance network, including apoptosis, anergy, and active suppression. Current excitement focuses on active suppression and new regulatory T cell-mediated pathways of immunosuppression that are being unraveled. Central to several of these pathways is transforming growth factor-beta (TGF-beta), a potent immunoregulatory cytokine that contributes to the function and generation of regulatory T cells.
对抗原或病原体产生充分的免疫反应与免疫耐受之间的平衡，是正常免疫稳态及宿主健康的先决条件。在这种复杂的自我调节过程中，多种机制被认为对免疫耐受网络有贡献，包括细胞凋亡、无反应性和主动抑制。当前的研究热点集中在主动抑制以及正在被揭示的由新型调节性T细胞介导的免疫抑制途径。这些途径中的几个关键因素是转化生长因子-β（TGF-β），它是一种强大的免疫调节细胞因子，对调节性T细胞的功能和生成有重要作用。
